Enzymatic Baeyer–Villiger oxidation of steroids with cyclopentadecanone monooxygenase
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Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation.
This paper describes the properties and partial purification from Pseudomonas testosteroni of enzymes concerned with the introduction of unsaturation into ring A of 3-ketosteroids. These enzymes promote the formation of the A1e4-diene-3-one structure from steroids bearing C-19 angular methyl groups and the formation of ring A phenols from lQ-nor-steroids. P. testosteroni is a strict aerobe whic...
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Information on steroid concentrations in tissues is important for an understanding of the metabolism of these substances and also for diagnostic purposes in certain clinical conditions. Existing procedures for determining steroids, either singly or in mixtures, are based upon calorimetric methods or tedious bioassays. The merits and limitations of these procedures have been critically appraised...
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Oxidation of urinary pregnane-17,20-diols (17.oxogenic steroids) by sodium metaperiodate is complete within 10 mm at 55#{176}C if the concentration of sodium metaperiodate at the end of the reaction exceeds 1.5 X 10-SM. A safe excess of sodium metaperiodate is present if assay samples, after incubation for 10 mm at 55#{176}C in 3 X 10-EM ethylene glycol, give a positive test with starch-iodide ...
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Kiessling, W. (1934). Biochem. Z. 273, 103. King, E. J. & Delory, G. E. (1939). Biochem. J. 33, 1185. King, H. & Pyman, F. L. (1914). J. chem. Soc. 105, 1238. Kumler, W. D. & Eiler, J. J. (1943). J. Amer. chem. Soc. 65, 2355. Martin, J. B. & Doty, D. M. (1949). Analyt. Chem. 21, 965. Meyerhof, 0. & Suranyi, J. (1926). Biochem. Z. 178, 427. Morton, C. (1930). Quart. J. Pharm. 3, 438. Nimms, L. F...
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ژورنال
عنوان ژورنال: Journal of Molecular Catalysis B: Enzymatic
سال: 2009
ISSN: 1381-1177
DOI: 10.1016/j.molcatb.2008.12.009